| Rank | Jugador | Equipo | Goles |
|---|---|---|---|
| 1 | Josef Martínez | Atlanta United | 35 |
| 2 | Ibrahimovic | Los Angeles Galaxy | 22 |
| 3 | Gyasi Zardes | Columbus SC | 20 |
| 4 | Bradley Wright-Phillips | New York RB | 20 |
| 5 | Mauro Manotas | Houston Dynamo | 19 |
| 6 | Ignacio Piatti | CF Montréal | 16 |
| 7 | Nemanja Nikolics | Chicago Fire | 15 |
| 8 | Damir Kreilach | Real Salt Lake | 15 |
| 9 | David Villa | New York City | 15 |
| 10 | Ola Kamara | Los Angeles Galaxy | 14 |
| 11 | Dániel Sallói | Sporting KC | 14 |
| 12 | Kei Kamara | Vancouver Whitecaps | 14 |
| 13 | Diego Váleri | Portland Timbers | 14 |
| 14 | Vela | Los Angeles | 14 |
| 15 | Daniel Royer | New York RB | 13 |
| 16 | Sebastian Giovinco | Toronto | 13 |
| 17 | R. Ruidíaz | Seattle Sounders | 13 |
| 18 | Dom Dwyer | Orlando City | 13 |
| 19 | Sebastián Blanco | Portland Timbers | 13 |
| 20 | Almiron | Atlanta United | 13 |
| 21 | Katai | Chicago Fire | 12 |
| 22 | Danny Hoesen | SJ Earthquakes | 12 |
| 23 | Rooney | D.C. United | 12 |
| 24 | Cristian Penilla | New England | 12 |
| 25 | Ismael Tajouri-Shradi | New York City | 12 |
| 26 | Adama Diomande | Los Angeles | 12 |
| 27 | Diego Rossi | Los Angeles | 12 |
| 28 | Romain Alessandrini | Los Angeles Galaxy | 11 |
| 29 | Teal Bunbury | New England | 11 |
| 30 | Albert Rusnák | Real Salt Lake | 11 |
| 31 | Alberth Elis | Houston Dynamo | 11 |
| 32 | Cory Burke | Philadelphia Union | 11 |
| 33 | Darwin Quintero | Minnesota United | 11 |
| 34 | Diego Rubio | Sporting KC | 10 |
| 35 | Johnny Russell | Sporting KC | 10 |
| 36 | Valeri Qazaishvili | SJ Earthquakes | 10 |
| 37 | Chris Wondolowski | SJ Earthquakes | 10 |
| 38 | Darren Mattocks | D.C. United | 10 |
| 39 | Luciano Acosta | D.C. United | 10 |
| 40 | Jonathan Osorio | Toronto | 10 |
| 41 | Fafà Picault | Philadelphia Union | 10 |
| 42 | Christian Ramirez | Los Angeles | 10 |
| 43 | Yamil Asad | D.C. United | 9 |
| 44 | Diego Fagúndez | New England | 9 |
| 45 | Dominique Badji | Dallas | 9 |
| 46 | Nicolás Lodeiro | Seattle Sounders | 9 |
| 47 | Maxi Moralez | New York City | 9 |
| 48 | Federico Higuaín | Columbus SC | 8 |
| 49 | Roland Lamah | Dallas | 8 |
| 50 | Maximiliano Urruti | Dallas | 8 |
| 51 | Corey Baird | Real Salt Lake | 8 |
| 52 | Joao Plata | Real Salt Lake | 8 |
| 53 | Víctor Vázquez | Toronto | 8 |
| 54 | Cristian Techera | Vancouver Whitecaps | 8 |
| 55 | Alphonso Davies | Vancouver Whitecaps | 8 |
| 56 | Armenteros | Portland Timbers | 8 |
| 57 | Héctor Villalba | Atlanta United | 8 |
| 58 | Felipe Gutiérrez | Sporting KC | 7 |
| 59 | Paul Arriola | D.C. United | 7 |
| 60 | Jefferson Savarino | Real Salt Lake | 7 |
| 61 | Jozy Altidore | Toronto | 7 |
| 62 | Will Bruin | Seattle Sounders | 7 |
| 63 | Miguel Ibarra | Minnesota United | 7 |
| 64 | Taïder | CF Montréal | 7 |
| 65 | Gerso | Sporting KC | 6 |
| 66 | Magnus Eriksson | SJ Earthquakes | 6 |
| 67 | Michael Barrios | Dallas | 6 |
| 68 | Santiago Mosquera | Dallas | 6 |
| 69 | Romell Quioto | Houston Dynamo | 6 |
| 70 | Kaku | New York RB | 6 |
| 71 | Sacha Kljestan | Orlando City | 6 |
| 72 | Ilsinho | Philadelphia Union | 6 |
| 73 | Yordy Reyna | Vancouver Whitecaps | 6 |
| 74 | Jesús Medina | New York City | 6 |
| 75 | Chris Pontius | Los Angeles Galaxy | 5 |
| 76 | Ilie Sánchez | Sporting KC | 5 |
| 77 | Zoltán Stieber | D.C. United | 5 |
| 78 | Luis Silva | Real Salt Lake | 5 |
| 79 | Tomás Martínez | Houston Dynamo | 5 |
| 80 | Derrick Etienne Jr. | New York RB | 5 |
| 81 | Víctor Rodríguez | Seattle Sounders | 5 |
| 82 | Borek Dockal | Philadelphia Union | 5 |
| 83 | Larrys Mabiala | Portland Timbers | 5 |
| 84 | Alejandro Silva | CF Montréal | 5 |
| 85 | Latif Blessing | Los Angeles | 5 |
| 86 | Bastian Schweinsteiger | Chicago Fire | 4 |
| 87 | Alan Gordon | Chicago Fire | 4 |
| 88 | Tommy Smith | Colorado Rapids | 4 |
| 89 | Wilfried Zahibo | New England | 4 |
| 90 | Reto Ziegler | Dallas | 4 |
| 91 | Sebastián Saucedo | Real Salt Lake | 4 |
| 92 | Philippe Senderos | Houston Dynamo | 4 |
| 93 | Alex Muyl | New York RB | 4 |
| 94 | Lucas Janson | Toronto | 4 |
| 95 | Chad Marshall | Seattle Sounders | 4 |
| 96 | Cristian Roldán | Seattle Sounders | 4 |
| 97 | Y. Yotún | Orlando City | 4 |
| 98 | Cristian Higuita | Orlando City | 4 |
| 99 | C.J. Sapong | Philadelphia Union | 4 |
| 100 | Ibson | Minnesota United | 4 |
